Seton Hall jumped on Notre Dame early, but the seventh-seeded Irish offset a 9-0 Pirates run with a 13-2 outburst en route to a 28-21 halftime lead.
Luke Harangody, who returned to action Saturday after suffering a knee injury and missing five games, helped spark the Irish attack.
He scored 15 points and grabbed nine rebounds in 15 minutes off the bench.
Jeremy Hazell leads No. 10 Seton Hall with nine points.