Kansas and Kentucky are undoubtedly the top teams, but can they survive a tough road to the Final Four?
Is No. 13 Siena really favored over No. 4 Purdue? How good is Baylor? What's with the Irish's new offense? The Spiders are always a fun pick, but they're not exactly a Cinderella ...
So many questions, and that's only one region.
Picking a winning NCAA bracket is a tedious chore that can drive you nuts, so let us help. Check out our regional breakdowns below to get the scoop on the best players, match-ups, coaches and potential first-round upsets of this year's tournament.
As always, check back on the blog throughout the week for the latest tournament analysis.
UPSET SPECIALS: Making a case for UTEP, Murray State, ODU and Cornell
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Photo: AP - Kansas guard Sherron Collins and Kansas State guard Jacob Pullen