Brady had three touchdown passes and tied for the third most yards passing in club history, going 31-for-40 with no interceptions as the Patriots (2-0) scored on each of their four first-half possessions.
The Chargers (1-1) turned the ball over inside the Patriots' 35-yard line three times, leading to 17 points. They also were stopped on a fourth-and-goal at the 1, and the Patriots started a 99-yard drive that ended with one of Brady's two scoring passes to tight end Rob Gronkowski.
Philip Rivers threw for 378 yards for the Chargers. Vincent Jackson caught 10 passes for 172 yards and a pair of touchdowns. The Chargers had four turnovers for the second straight year against New England after losing 23-20 in 2010 when the Patriots gained just 179 yards.
Vince Wilfork, the Patriots' 325-pound defensive tackle, got his first career interception to halt a promising Chargers drive late in the first half, rumbling 28 yards on the return.
For the second straight game, New England had a 99-yard touchdown drive. After Stephen Gostkowski's 22-yard field goal made it 10-7, the Patriots got the ball back at their 1-yard line when Jerod Mayo stopped Mike Tolbert short of the goal line. -- AP