Brady threw for three touchdowns in a 34-3 rout of the Bills Sunday and extended his streak of attempts without an interception to 319 - topping the NFL mark of 308 set by Bernie Kosar with Cleveland in the 1990 and 1991 seasons.
Rookie tight end Rob Gronkowski, who is from Buffalo, caught two touchdowns in leading the Patriots (13-2) to their seventh consecutive win and clinch the AFC East title and home-field advantage throughout the AFC playoffs.
Alge Crumpler had a 4-yard touchdown catch, Danny Woodhead scored on a 29-yard run and Shayne Graham hit two field goals as the Patriots continued their domination over Bills (4-11). New England has now won 15 straight against Buffalo - a streak dating to 2003 - and 20 of the past 21 meetings.
Brady finished 15-for-27 for 140 yards, and has gone nine games without an interception since throwing two in a 23-20 win over Baltimore on Oct. 17. Gronkowski finished with four catches for 54 yards, and now has nine TDs.
The Patriots have now scored at least 31 points in their last seven games, and have topped the number 10 times this season. Brady, who has 34 TD passes this season, has thrown for a touchdown in all 15 games this season, and could become only the seventh NFL player to throw a touchdown pass in all 16 games.
Brady broke Kosar's record with his 17th attempt early in the third quarter, when Gronkowski dropped a pass over the middle at the goal line. The two hooked up on the next play for an 8-yard touchdown.