DETROIT — The Lions (1-2) suddenly looked like a team with a plan on offense and defense under their first-year coach, and former New England assistant. They opened the season with a 31-point loss to the New York Jets at home and fell short in a comeback at San Francisco.
The Patriots (1-2) have had weaknesses exposed on both sides of the ball, losing two of their first three games for the first time since 2012.
Detroit was in control from the start, creating holes for rookie running back Kerryon Johnson and giving Matthew Stafford time to pass.
Johnson had 101 yards rushing on 16 carries, becoming the first player to reach the mark for the Lions since Reggie Bush ran for 117 yards against Green Bay on Nov. 28, 2013. Detroit's 70-game stretch without a 100-yard rusher was the longest since the NFL-AFL merger.
Tom Brady pulled the Patriots within three points on a 10-yard TD pass to James White early in the third.
Detroit refused to let the five-time Super Bowl-winning quarterback get any closer.
Stafford responded with a 33-yard TD pass, capping a 10-play, 75-yard drive that took more than 6 minutes off the clock.
Darius Slay picked off Brady's pass at the Detroit 15 midway through the fourth quarter, helping the Lions seal the win.