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NFL Week 6 picks

Tom Brady of the New England Patriots cheers

Tom Brady of the New England Patriots cheers as he runs on to the field before the game against the Pittsburgh Steelers at Gillette Stadium on September 10, 2015 in Foxboro, Massachusetts. Credit: Getty Images


REDSKINS (2-3) AT JETS (3-1)

TV: Ch. 5; Radio: ESPN (98.7)

Jets by 6; O/U: 40 1/2

You never want to look ahead to next week's game, but it's hard to believe the Jets haven't. On deck is a trip to face the rival Patriots, who look like they'll run away with another AFC East title. In other words: Take care of business against an opponent you should beat at home. Enter the Redskins, who are coming off back-to-back down-to-the-wire games. Last week, they outplayed Atlanta on the road for most of the game before losing on a pick-6 in overtime. Will they be up for this one? The Jets were on a bye last week after their easy London win, so they'll have the fresher legs. The Jets (second-ranked) and Redskins (sixth-ranked) have two of the top defenses in the NFL, so expect a low-scoring game. But I think the Jets learned their lesson from the Eagles loss at home, and do enough on offense to not make the same mistake again. (No laterals, Brandon Marshall!)

The pick: Jets


Broncos by 4; O/U: 42 1/2

If you were on a five-week, football-free vacation and returned to learn that Peyton Manning had more INTs (7) than TDs (6), you'd think Denver is struggling. But they're 5-0, thanks to the defense. Its five wins are by a combined 34 points. Cleveland showed some guts with an OT win at Baltimore last week, and I have a gut feeling they'll be up for this game more than Denver. Broncos won "The Drive" and "The Fumble." With John Elway in the building, I can see Browns getting revenge. If not, then at least "The Cover."

The pick: Browns

BENGALS (5-0) AT BILLS (3-2)

Bengals by 3; O/U: 42 1/2

Cincy rallied to stun Seattle last week, and I think that momentum carries over. Buffalo has followed up each of its first two wins with a loss the next week.

The pick: Bengals


Radio: WNYM (970)

Cardinals by 3 1/2; O/U: 44 1/2

Le'Veon Bell saved Pittsburgh's season with a time-expiring TD Monday night. Talk about momentum. There's talk that Ben Roethlisberger may be able to play in rematch of Super Bowl XLIII. I'll lean toward home team getting points.

The pick: Steelers


Titans by 1 1/2; O/U: 43 1/2

Team fires coach, back that team in their next game. Dolphins will be pumped up to play for a former player. Interim coach Dan Campbell, 39, brings intensity, something laid-back Joe Philbin didn't. Bill Parcells, Campbell's former coach, said: "You are what your record says you are." At 1-3, Miami is a last-place team. On Sunday, they start new season 1-0.

The pick: Dolphins


Vikings by 4; O/U: 43 1/2

Kansas City has lost four in a row, and its best player, Jamaal Charles. Vikings, off a bye, have won both home games by a combined 27 points. This one isn't close.

The pick: Vikings

BEARS (2-3) AT LIONS (0-5)

Lions by 3; O/U: 431 /2

Lions and Bears, oh why? I'll take another shot with Detroit, because, hey, they can't possibly go 0-16 again, right . . . right?

The pick: Lions


Pick 'em; O/U: 42 1/2

Jags might be a rare favorite by kickoff, which shows how bad Texans are. Take JJ (Jacksonville Jaguars) over J.J. (Watt).

The pick: Jaguars


TV: Ch. 2, 4:25 p.m.

Radio: WFAN (660, 101.9)

Packers by 10 1/2; O/U: 50 1/2

Pack covered a similar spread last week despite not playing its best. Aaron Rodgers throws 3-plus TDs against Bolts, who looked flat in two previous road losses.

The pick: Packers


Seahawks by 7; O/U: 40 1/2

Carolina's four wins have been vs. teams with combined 5-15 record. Off a bye, they face an angry Seattle team that last week blew 17-point lead. Bad spot for Carolina.

The pick: Seahawks

RAVENS (1-4) AT 49ERS (1-4)

Ravens by 2 1/2; O/U: 44

The only key figure still smiling from Super Bowl XLVII? Michigan coach Jim Harbaugh. The 49ers have been respectable at home, and get some Ravenge against a Baltimore team that's just a mess. The pick: 49ers


LOCK OF THE WEEK: PATRIOTS (4-0) AT COLTS (3-2), 8:20 p.m.

TV: Ch. 4; Radio: WFAN (660, 101.9)

Patriots by 10; O/U: 54 1/2

There are "circle the calendar" games, and then there are "circle the calendar, make copies and paste them all over the building" kind of games. This is that game for the Pats. Tom Brady and Bill Belichick will be out for blood against the team that tipped off the NFL and got the (underinflated) ball rolling on DeflateGate. The Pats' 2015 season has been an encore of 2007 as they've outscored opponents 149-76. Through four games in 2007, it was 148-48. They're on pace to score 596 points, which would surpass the 589 in 2007. Brady is completing 72.5 percent of his passes for 1,387 yards, 11 TDs and no INTs. The Colts have won three in a row, the last two without Andrew Luck. He will probably play, but I don't care if it's Johnny Unitas out there, there's no chance Indy wins. There's a reason this spread has inflated to 10 points: Brady and Belichick, kings of running up the score, take it to a new height. LOCK. OF. THE. YEAR. Patriots 55, Colts 21.

The pick: Patriots


GIANTS (3-2) AT EAGLES (2-3), 8:30 p.m.

TV: ESPN, Ch. 11; Radio: WFAN (660, 101.9)

Eagles by 4; O/U: 49 1/2

Two weeks into the season, the Giants and Eagles were 0-2, had both lost to Dallas and were two games behind the Cowboys. What a difference three weeks makes. The first-place Giants have won three straight, and the Eagles have won two of three. Philly's offense finally got untracked with a 39-point effort last week, but that was against the Saints. I'm still not sold. Eagles are allowing 279.6 passing yards per game (26th in NFL), and Giants are allowing 304.2 (last), so this could be a shootout. Eli Manning (10 TDs, 2 INTs) has another big night. Playing on Monday night gives Odell Beckham Jr. an extra day to heal his hamstring. I like Giants to win outright, so getting four points is added bonus.

The pick: Giants

STAFF PICKS (Best bet in caps)

JOE MANNIELLO (37-38-2 overall, 3-1-1 best bets; Last week: 6-7-1): Jets Giants Browns Bengals Steelers Dolphins Vikings Lions Jaguars Packers Seahawks 49ers PATRIOTS

BOB GLAUBER (40-35-2, 2-3; Last week: 7-6-1): Jets Eagles Broncos Bengals Cardinals Dolphins VIKINGS Lions Jaguars Packers Seahawks 49ers Patriots

TOM ROCK (36-39-2, 4-0-1; Last week: 4-9-1): Jets Eagles Broncos BENGALS Cardinals Dolphins Vikings Lions Jaguars Packers Panthers Ravens Patriots

KIMBERLEY A. MARTIN (38-37-2, 2-3; Last week: 4-9-1): Jets Eagles Broncos Bengals Cardinals Dolphins Vikings Bears Texans Chargers Seahawks Ravens PATRIOTS


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