Christina Applegate fears that 'poisoning' may be behind her misdiagnosis of MS

Christina Applegate, seen in 2023, spoke about a possible cause of her multiple sclerosis-like symptons on the latest episode of the "MeSsy" podcast. Credit: AFP / Getty Images / TNS / Valerie Macon
Christina Applegate has a theory about why she was misdiagnosed with multiple sclerosis: She's been poisoned.
The "Married With Children" and "Dead to Me" star has been inundated with well-intentioned suggestions following her public revelation of her misdiagnosis in October, but one stood out, Applegate recounted on Tuesday's episode of her "MeSsy" podcast with her Jericho-raised co-host Jamie Lynn Sigler.
"I've been thinking this for years: breast implant poisoning," she said. "I actually had my double mastectomy in 2008, and I am way overdue for having them replaced, and I swear over the last five years or whatever I thought, 'What if it's — seriously — what if they're leaking and they're poisoning me?"
Someone sent her a study about breast implant leakage and poisoning presenting as MS, Applegate said, recounting some of her symptoms.
For one, she said, "I sleep, Jamie. I can't stop sleeping. I slept, I think, almost the entire day yesterday. I had like one thing that was important for me to do and then other than that, I'm like — I'm, like, asleep right now."
Then there's the pain.
"I don't know what's going on in my joints, but I can't move my right shoulder, like, at all now. I can't lift my arm. I've got all sorts of other things going on," Applegate told "Sopranos" star Sigler, who has lived with MS for over a decade. "It takes me 10 minutes at least to even sit up and get out of my bed, because I just hurt all over. And I don't know if I'm doing that to myself by sleeping too much."
MS is a central nervous system (brain, spinal cord, optic nerves) disease that "disrupts the flow of information within the brain and between the brain and the rest of the body," according to the National Multiple Sclerosis Society. Symptoms may include fatigue, memory and mobility issues, mood swings, numbness, pain, tingling and vision impairment.
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