CAPE CANAVERAL, Fla. - Astronauts ran into trouble yesterday while setting up the International Space Station's newest room, Tranquility: A critical insulating cover does not fit.

The fabric, multilayered cover is supposed to go between Tranquility and its observation deck, but the metal bars are not locking down properly because of interference from a hand rail or other structure at the hatch.

Flight director Bob Dempsey said engineers are trying to figure out how to proceed. Until this snag, everything had been going smoothly in NASA's final major construction job at the space station. Shuttle Endeavour delivered Tranquility and the attached lookout - an enormous bay window - earlier this week.

The cover is needed to protect Tranquility's seals and docking mechanisms from the cold. This port will be exposed, temporarily, when the domed lookout is moved to its permanent location on the other side of Tranquility. That relocation is supposed to happen todday, but may be delayed.

Dempsey said the astronauts may be asked to remove the interfering pieces or, possibly, do away with the cover entirely and proceed with the original relocation plan.

Another option, Dempsey said, may be to hold off on moving the observation deck until a properly fitting cover can be flown on another shuttle flight. Only four more shuttle missions remain. The next visit is scheduled for mid to late March.

The $27-million, Italian-built observation deck sports the biggest window ever flown in space. In all, there are seven windows that will offer 360-degree views.

The 11 astronauts aboard the shuttle-station complex opened the door Friday to the $380-million Tranquility, also made in Italy for the European Space Agency. The door leading from Tranquility into the observation deck was opened soon afterward, and that's when shuttle pilot Terry Virts and Kay Hire encountered the cover problem.

That didn't stop the astronauts from routing cables and water lines into Tranquility, and hauling in an exercise machine and other equipment.

"I will tell you, we're filling it up very quickly," Hire said. "We're loading all kinds of equipment in there and starting to bring it to life."

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