Pittsburgh Steelers' Ben Roethlisberger throws against the Buffalo Bills during...

Pittsburgh Steelers' Ben Roethlisberger throws against the Buffalo Bills during the first half. (Nov. 28, 2010) Credit: AP

JETS (9-2) at PATRIOTS (9-2)

Line: Patriots by 3 1/2

Over/Under: 46

TV-Radio: ESPN, Ch. 9, ESPN (1050), 8:30 p.m.

This is the NFL's biggest game of the season yet. The Jets are 10-2 ATS their last 12 December road games; the Pats are 4-10 ATS their last 14 home games vs. Jets. But the eyeball test tells me otherwise: The Pats are the better play. Tom Brady has won an NFL-record 25 straight regular-season home games.

The pick: Patriots

REDSKINS (5-6) at GIANTS (7-4)

Line: Giants by 7

Over/Under: 43 1/2

TV-Radio: Ch. 5, WFAN (660), 1 p.m.

Justin Tuck got all the credit for inspiring his teammates, but I think it was because I picked the Jags. Washington is 1-6-1 ATS vs. the Giants in its last eight games on the road.

The pick: Giants

STEELERS (8-3) at RAVENS (8-3)

Line: Ravens by 3

Over/Under: 40

TV-Radio: Ch. 4, 8:20 p.m., WFAN (660)

Steelers QB Ben Roethlisberger has been walking around practice in a boot on his right, plant foot, but reportedly will be ready to go. The winner here, along with the Pats-Jets winner, will have the inside track for the top two AFC playoff spots. The Steelers are 1-6 in their last seven trips to Baltimore.

The pick: Ravens

FALCONS (9-2) at BUCS (7-4)

Line: Falcons by 3

Over/Under: 44 1/2, 4:15 p.m.

The Falcons showed they are the top team in the NFC last week. But Atlanta always struggles against the spread vs. the Bucs (1-5 in its last six trips to Tampa Bay). I know the Bucs have covered five straight, but Atlanta is the class of the NFC, and too strong right now.

The pick: Falcons

RAIDERS (5-6) at CHARGERS (6-5)

Line: Chargers by 13

Over/Under: 47, 4:05 p.m.

Five weeks ago, Oakland was riding high and San Diego was in a funk. Now, San Diego may not lose another game!

The pick: Chargers

JAGUARS (6-5) at TITANS (5-6)

Line: OFF (Titans QB questionable)

Over/Under: OFF, 1 p.m.

It doesn't matter who starts; Tennessee is kaput.

The pick: Jaguars

BRONCOS (3-8) at CHIEFS (7-4)

Line: Chiefs by 8 1/2

Over/Under: 48 1/2, 1 p.m.

Coach Todd Haley and KC want payback against Josh McDaniels and Denver for running up the score. Forget about shaking hands; Haley's going to be doing cartwheels after this one.

The pick: Chiefs

BROWNS (4-7) at DOLPHINS (6-5)

Line: Dolphins by 4 1/2

Over/Under: 43, 1 p.m.

Cleveland is 12-5 ATS in its last 17 AFC games.

The pick: Browns

BEARS (8-3) at LIONS (2-9)

Line: Chicago by 4 1/2

Over/Under: 44 1/2, 1 p.m.

If the Bears could stop Michael Vick, then Drew Stanton has no chance.

The pick: Bears

BILLS (2-9) at VIKINGS (4-7)

Line: Vikings by 5 1/2

Over/Under: 44 1/2, 1 p.m.

I just got a tweet from BigManUpstairs: Tell Steve Johnson to keep his eyes on the ball.

The pick: Bills

COWBOYS (3-8) at COLTS (6-5)

Line: Colts by 5 1/2

Over/Under: 47 1/2, 4:15 p.m.

4 INTs to 4 TDs: Peyton Manning bounces back.

The pick: Colts

49ERS (4-7) at PACKERS (7-4)

Line: Packers by 9 1/2

Over/Under: 41 1/2, 1 p.m.

Green Bay is 13-2 overall and 11-2-2 ATS in its last 15 games vs. the Niners.

The pick: Packers

PANTHERS (1-10) at SEAHAWKS (5-6)

Line: Seattle by 6

Over/Under: 40, 4:15 p.m.

Seattle is 8-2 in its last 10 December home games.

The pick: Seahawks

RAMS (5-6) at CARDINALS (3-8)

Line: Rams by 3 1/2

Over/Under: 43, 4:15 p.m.

Arizona, last in the worst division in the NFL, has no reason to be laughing.

The pick: Rams

SAINTS (8-3) at BENGALS (2-9)

Line: Saints by 6 1/2

Over/Under: 46, 1 p.m.

The defending champs haven't played a full, 60-minute game thus far. That changes.

The pick: Saints

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