Tight end Larry Donnell of the Giants catches a pass...

Tight end Larry Donnell of the Giants catches a pass for a touchdown against the Washington Redskins during their game at FedExField on Sept. 25, 2014 in Landover, Md. Credit: Getty Images / Patrick Smith

FALCONS (2-2) at GIANTS (2-2), 1 p.m.

Giants by 4; O/U: 50 1/2

TV: Ch. 5; Radio: WFAN (660, 101.9)

The best Week 4 story was the Giants' Larry Donnell. Guess whom Donnell had on his fantasy football bench at tight end last week? That's right, himself. He started the Niners' Vernon Davis (two catches for eight yards) instead. Can you say, D'oh-nell! Meanwhile, Donnell caught three TD passes. "Would have won," he said, "if I had played me." Don't start the Falcons' defense this week. Eli Manning looked great last week, and he's 29-7 overall in October. Atlanta is 3-7 against the spread (ATS) in its last 10 road games. Remember what happened the last time Atlanta visited MetLife Stadium? A 24-2 wild-card loss in 2012. Matt Ryan & Co are a different team outdoors. Big Blue winning streak hits 3.

The pick: Giants

JETS (1-3) at CHARGERS (3-1), 4:25 p.m.

Chargers by 6 1/2; O/U: 43 1/2

TV: Ch. 2; Radio: ESPN (98.7)

It's time to hit, slam and smash the panic button for the Jets. They'll be challenged against Philip Rivers and the Chargers, who are 4-0 ATS this season. Also, the Bolts are 4-2 ATS in their last six games vs. AFC East teams. The Jets are 2-4-2 ATS in their last eight road games, and 6-13-1 in last 20 games as underdogs of eight or fewer points. It's not all Geno Smith's fault, but the Jets can't afford any more losses, especially in a season where the AFC East is very much up for grabs. My crystal ball tells me Michael Vick starts at home next week vs. Denver, maybe even the second half in San Diego if Geno's struggles continue.

The pick: Chargers

BEARS (2-2) at PANTHERS (2-2)

Panthers by 2 1/2; O/U: 45 1/2

Things are so bad in Carolina that the team's lone healthy running back in Week 4, DeAngelo Williams, tweeted a picture of his right ankle in a cast this week. The Bears are 8-17 ATS in their last 25 games, but the Panthers probably have to start undrafted rookie back Darrin Reaves. Gut-feel pick.

The pick: Bears

STEELERS (2-2) at JAGUARS (0-4)

Steelers by 6; O/U: 47

Pittsburgh joins Seattle as the only two Week 5 road favorites, Road faves are 7-8-1 ATS, while home favorites are 20-24-1 ATS. Early reviews of Jags rookie QB Blake Bortles are positive, but it's tough to back a team that loses by an average score of 38-15.

The pick: Steelers

BUCS (1-3) at SAINTS (1-3)

Saints by 10; O/U: 48

Underdogs are 32-27-2 ATS this season. Still, it's tough to take the Bucs, who have dropped seven straight covers against NFC opponents and are 0-4 vs. NFC South foes. Home team has covered five of last six meetings.

The pick: Saints

RAMS (1-2) at EAGLES (3-1)

Eagles by 7; O/U: 47 1/2

All the numbers lean toward the Rams, who are 11-5 ATS in their last 16 games against winning teams. Philly has not been a good home bet in recent years -- 7-22-1 ATS in their last 30 home games -- but it gets tackle Lane Johnson back from suspension. The O-line should get healthy vs. Rams' 'D' that is 30th vs. the run (155 yards per game) and in points allowed (28.3).

The pick: Eagles

RAVENS (3-1) at COLTS (2-2)

Colts by 3; O/U: 48

I'm still not sold on either team as an AFC contender yet. The Colts are 7-3 ATS as favorites of four or fewer points, and are 16-5 ATS in last 21 home games. Coin flip.

The pick: Colts

BILLS (2-2) at LIONS (3-1)

Lions by 7; O/U: 44

The Lions -- 2-5 ATS in their last seven games following a cover - welcome former coach Jim Schwartz, now Buffalo's defensive coordinator. Maybe QB Kyle Orton can right the ship in Buffalo. Worth a shot.

The pick: Bills

BROWNS (1-2) at TITANS (1-3)

Titans by 2; O/U: 441/2

Titans have dropped three straight covers after season-opening win. Brownies are 2-0-1 ATS, and are coming off a bye. Cleveland is 33-88 overall on the road since 1999, and hasn't won away from the Dawg Pound since Sept. 22, 2013, a span of seven straight losses. Streak stops here.

The pick: Browns

TEXANS (3-1) at COWBOYS (3-1)

Cowboys by 6; O/U: 46 1/2

Did Jerry Jones bring back former greats Nate Newton, Larry Allen and Mark Stepnoski? How 'bout that Cowboys' O-line! It's no surprise DeMarco Murray is the fourth RB in league history with 100 yards rushing and a TD in his first four games to start a season. Dallas keeps it going.

The pick: Cowboys

CARDINALS (3-0) at BRONCOS (2-1), 4:05 p.m.

Broncos by 7 1/2; O/U: 48 1/2

Cardinals QB Drew Stanton has filled in admirably, and it doesn't hurt that Arizona has the NFL's No. 5 defense. But this is a bad spot for the Cards. Denver, which has yet to cover this season, is 6-0 ATS in its last six games following a loss, and 13-6-1 in its last 20 on grass. Peyton Manning's next TD pass gives him 500 for his career. Amazing.

The pick: Broncos

CHIEFS (2-2) at 49ERS (2-2), 4:25 p.m.

49ers by 6; O/U: 44

I wonder how Chiefs QB Alex Smith will feel Sunday? The Niners' former No. 1 pick was jettisoned to KC a couple seasons ago with the emergence of Colin Kaepernick. Smith told reporters this week he has "no bitterness at all" toward his former club. He's a better guy than me! Smith and the Chiefs -- 9-2 ATS in last 11 regular and postseason road games -- keep this close enough.

The pick: Chiefs

BENGALS (3-0) at PATRIOTS (2-2), 8:30 p.m.

Bengals by 1; O/U: 46

TV: Ch. 4; Radio: WFAN (660, 101.9)

The Pats' loss at KC was their worst defeat in nine years. Bill Belichick refused to talk about it during Wednesday's media session, only saying: "We're on to Cincinnati." Yeah, good luck with that, coach! The Bengals are 20-8-1 ATS in their last 29 games. Move over Pats and make room for a new AFC heavyweight.

The pick: Bengals

SEAHAWKS (2-1) at REDSKINS (1-3), 8:30 p.m.

Seahawks by 7; O/U: 45 1/2

TV: ESPN; Radio: WFAN (660, 101.9)

Wait, did Kirk Cousins just get intercepted again? Too easy. I know Washington isn't as bad as it looked against the Giants, and the extra time off will help. However, Seattle is coming off a bye, and is 11-3 ATS in its last 14 on the road. Ride the defending champs.

The pick: Seahawks

STAFF PICKS (against the spread; best bets in caps)

JOHN BOELL 31-28-1 overall, 1-3 best bets; Last week: 4-8-1

Giants Chargers Bears Steelers Saints Eagles Colts Bills Browns Cowboys Broncos Chiefs Bengals SEAHAWKS

BOB GLAUBER 26-33-1, 1-3; Last week: 8-4-1

Giants Jets Panthers Steelers Saints Eagles Colts LIONS Titans Texans Broncos 49ers Patriots Seahawks

TOM ROCK 27-32-1, 1-3; Last week: 5-7-1

Giants Jets Bears Jaguars Saints Rams COLTS Bills Browns Cowboys Broncos Chiefs Bengals Seahawks

KIMBERLEY A. MARTIN 31-28-1, 1-3; Last week: 7-5-1

Giants Jets Bears Steelers Saints Eagles Colts Lions Browns Texans Broncos 49ERS Patriots Seahawks