Leonardo DiCaprio and Blake Lively break up

It’s splitsville for Hollywood’s best-looking couple — and we’re not talking about Demi Moore and Ashton Kutcher.

Leonardo DiCaprio and Blake Lively have called it quits, a rep for the “Gossip Girl” actress confirmed to amNewYork Tuesday.

Reports cited busy work schedules as the reason for the breakup. And, apparently, the celebri-exes plan to stay friends.

The two were first spotted together during May’s Cannes Film Festival getting cozy aboard a super-luxe yacht.

Their summer romance continued with stops around the world, including Italy, Sydney, Los Angeles and New York — Lively’s homebase, since “Gossip Girl” is shot here.

Our fave Big Apple moment from the duo’s summer vacay? Seeing the casually dressed, sunglasses-clad DiCaprio, 36, and Lively, 24, riding their bikes through the streets of Manhattan.

Before Lively, DiCaprio dated Israeli model Bar Refaeli on and off for five years (The two reporptedly split up right before DiCaprio got together with Lively.)

Lively and her “Gossip Girl” co-star, Penn Badgley, broke up last October after dating for three years.

Follow Style/Entertainment Editor Julie Gordon on Twitter: @jbgordon