SAN FRANCISCO -- Matt Cain tossed and turned and got about four hours of sleep after his history-making gem for the Giants. Perfectly understandable.

Cain's perfect game will be remembered among the most masterful pitching performances in regular-season history, if not ever.

The ace righthander dominated the Astros Wednesday night in a 10-0 win for the 22nd perfect game ever and the fifth no-hitter already this year. He struck out a career-best 14, tying Hall of Famer Sandy Koufax for the most in a perfecto. Cain (8-2) never faced a 2-and-0 count in winning his seventh straight start.

"I'm still pumped," said Cain, who after a workout was back on the field playing catch with fellow starter Madison Bumgarner by 10:15 a.m. yesterday. "I don't know that it has hit me yet.''

Philip Humber of the White Sox threw a perfect game April 21 at Seattle. It's the second time in three years there have been two perfect games in a season -- before that, the only other time it happened was in 1880. Of the 22 perfect games, 11 have come in the last 24 years.

Aided by improbable catches by Melky Cabrera and Gregor Blanco, Cain threw the first perfect game in the franchise's storied 130-year history and its 14th no-hitter. He threw 125 pitches -- most ever in a perfect game -- 86 for strikes. He didn't shake off Buster Posey once.

"It's something I always wanted to do since I was little,'' Cain said, "but it's kind of a blur when it actually happens."

It wasn't all good for the Giants. An MRI indicated Aubrey Huff sprained his right knee trying to jump over the dugout railing and join the celebration. On June 1, the Mets' Ramon Ramirez injured a hamstring running in from the bullpen after Johan Santana's no-hitter.

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