Toronto Blue Jays' Vladimir Guerrero Jr. (27) runs the bases...

Toronto Blue Jays' Vladimir Guerrero Jr. (27) runs the bases after hitting a solo home run against the San Diego Padres during the first inning of a baseball game in Toronto on Tuesday, May 20, 2025. Credit: AP/Jon Blacker

TORONTO — Anthony Santander and Vladimir Guerrero Jr. homered, Chris Bassitt and three relievers combined on a five-hitter and the Toronto Blue Jays beat the San Diego Padres 3-0 on Tuesday night.

The shutout was Toronto’s first of the season. The Padres failed to score a run for the third time this season.

San Diego lost its fourth straight, matching its longest losing streak of the season. The Padres also lost four in a row from April 23-27.

Blue Jays right-hander Chris Bassitt (4-2) allowed four hits, walked one and struck out six in six innings.

Brendon Little worked the seventh, Yariel Rodríguez pitched the eighth and Jeff Hoffman finished for his 10th save in 12 opportunities.

Padres right-hander Dylan Cease (1-3) allowed three runs and three hits in seven innings. Cease hasn’t won in eight starts, failing to record a victory since April 2 against Cleveland. He has allowed three runs or fewer in seven of those outings.

San Diego lost for the first time when its starter worked at least seven innings. The Padres had been 5-0 in such games.

Toronto Blue Jays starting pitcher Chris Bassitt (40) throws to...

Toronto Blue Jays starting pitcher Chris Bassitt (40) throws to a San Diego Padres batter during first inning MLB baseball action in Toronto on Tuesday, May 20, 2025. Credit: AP/Jon Blacker

Guerrero opened the scoring with a one-out homer to left in the bottom of the first, his sixth.

Santander made it 3-0 with a two-run drive in the fifth, his sixth.

Key moment

Santander homered for the first time since May 6 against the Angels. Tuesday’s two-run drive was Santander’s first homer since being dropped to fifth in the order Sunday.

Key stat

The Padres went 0 for 3 with runners in scoring position, the fourth straight game they’ve gone hitless in those situations.

San Diego Padres left fielder Jason Heyward (22) watches Toronto...

San Diego Padres left fielder Jason Heyward (22) watches Toronto Blue Jays' Vladimir Guerrero Jr.'s solo home run clear the fence during the first inning of a baseball game in Toronto on Tuesday, May 20, 2025. Credit: AP/Jon Blacker

Up next

RHP Kevin Gausman (3-4, 4.59 ERA) is scheduled to start for the Blue Jays on Wednesday against Padres RHP Randy Vásquez (3-3, 3.45).

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