Philadelphia Eagles defensive end Trent Cole, left, reaches for Green...

Philadelphia Eagles defensive end Trent Cole, left, reaches for Green Bay Packers running back James Starks (44) during the second half of an NFL football NFC wild-card playoff game in Philadelphia, Sunday, Jan. 9, 2011. The Packers defeated the Eagles 21-16. (AP Photo/Rob Carr) Credit: AP Photo/Rob Carr

Not only are the Eagles off to a 1-3 start after blowing a second-half lead against the 49ers yesterday, but they're also getting banged up in a big way. 

The team's top defensive player, pass rusher Trent Cole, is out with what head coach Andy Reid says is a "fairly significant" injury. Cole suffered a severe calf strain in the loss. 

What's more, left tackle Jason Peters suffered a hamstring injury in the fourth quarter that Reid also terms "fairly significant." 

In a word: ouch. 

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