CDC: American cigarettes contain more lethal carcinogens

LOS ANGELES - Cigarette-smoking Americans receive higher doses of the most potent carcinogens than do smokers in many foreign countries because of variations in the way tobacco is processed for cigarettes, researchers from the Centers for Disease Control and Prevention have reported.

American cigarettes are typically made from "American blend" tobacco, a specific blend that, because of growing and curing practices, contains higher levels of cancer-causing tobacco-specific nitrosamines. The most popular Canadian, Australian and British brands, in contrast, are made from "bright" tobacco, which is lighter in color and cured differently.

The study, reported by the CDC Monday, was designed primarily to correlate how well levels of the chemicals in cigarettes correlate with levels of their metabolites in smokers' urine. The data about exposure to the chemicals in different countries were an added benefit.

The CDC team enlisted 126 regular smokers in Australia, Canada, Britain, and in New York and Minnesota. All smoked one brand routinely, typically the most popular brands in their country.

Smokers in Minnesota smoked Marlboro, Newport, Marlboro Light and Camel Light, while those in New York smoked Marlboro, Newport, Newport Light, Camel Light and Marlboro Menthol.

The team focused on the most lethal carcinogen in the tobacco smoke, 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK), and its primary metabolite in urine, known as NNAL.

The team reported in the journal Cancer Epidemiology Biomarkers and Prevention that the amount of NNAL in urine was directly related to the amount in the cigarette butts and that significantly higher levels were found in U.S. smokers, higher in New Yorkers than in Minnesotans. The lowest levels were found in Australia and Canada.