Patrick Mahomes throws 5 TDs, Kansas City hammers Cardinals

GLENDALE, Ariz. — Patrick Mahomes threw for 360 yards and five touchdowns, lifting Kansas City to an impressive 44-21 road win over the Arizona Cardinals on Sunday in the opener for both teams.

The game was never in doubt after the opening minutes, with Mahomes picking apart the Cardinals' defense with his usual array of good decisions and deft passing touch. The quarterback was playing his first NFL game against Kliff Kingsbury, who coached Mahomes in college at Texas Tech and now leads the Cardinals.

The student put on quite a show for his mentor: The 2018 MVP threw three touchdown passes on Kansas City's first three drives.

Tight end Travis Kelce caught eight passes for 121 yards and a touchdown. It was his 30th career game with at least 100 yards receiving. Clyde Edwards-Helaire hauled in two touchdown passes.

Kansas City outgained Arizona 488 yards to 282. Mahomes completed 30 of 39 passes.

The onslaught started in a hurry.

Kansas City jumped out to a 7-0 lead on the opening drive, capping an 11-play, 75-yard march with a 9-yard touchdown pass from Mahomes to Kelce. KC pushed ahead 14-0 later in the first on a nifty play from Mahomes, who threw an underhanded shovel pass to Edwards-Helaire for the 3-yard score.

The visitors led 23-7 by halftime after Harrison Butker, who missed part of the first half with a left ankle injury, made a 54-yard field goal with two seconds left in the second quarter.

Kansas City — which is trying to make the AFC title game for a fifth straight season — had a 37-7 advantage by the fourth quarter.

It was a rough start for Arizona, which also suffered through a brutal ending to 2021. The Cardinals have lost six of seven games dating to last season, including the playoffs.

Cardinals quarterback Kyler Murray was playing his first game since being rewarded with a $230.5 million, five-year contract during the offseason. He finished 22-of-34 passing for 193 yards and two touchdowns, though much of that production came when Kansas City already had control of the game.

The Cardinals came into Week 1 missing some of their best players. Three-time All-Pro receiver DeAndre Hopkins was suspended for the season's first six games after violating the NFL's performance-enhancing drug policy. Star defensive lineman J.J. Watt was inactive because of a calf injury.